Road traffic crashes are a leading cause of morbidity and mortality in Nepal. The World Health Organisation estimated that Nepal's road traffic fatality rate is one of the highest in South-East Asia at 17 per 100,000 population. The aim this study is to improve our understanding of the scale and nature of road dangers in the Makwanpur District of Nepal. Fieldwork will focus on three sites located along the East-West Highway, where collisions and casualties have been found to be particularly high: Pushupatinagar, Nawalpur, and Basamadi. The study will include the collection and analysis of locally collected road traffic collision and casualty data, analysis of police-recorded collision and casualty data, monitoring of motorised vehicle speeds through use of a roadside speed gun, and recording of traffic flows and public use of the road space through roadside observation. We aim to start fieldwork in April 2019 and the study will be completed in April 2020. Qualitative research will explore knowledge and attitudes relating to road danger and will involve the local communities, truck drivers and school children.The findings will provide a baseline for a potential before-and-after natural experiment study of the impact on road danger of the reconstruction of the East-West Highway through Makwanpur. The study team will also seek to influence the reconstruction of the East-West Highway, through dissemination of the findings of this study with key stakeholders.Elements of the study will be supported by Mother and Infant Research Activities (MIRA). components.